研究领域

单分子生物物理实验（单分子操纵与荧光）与理论分子建模与模拟），蛋白质的力学响应，蛋白质去折叠与折叠动力学，蛋白质与核酸的相互作用

教育和工作经历

2013-今：厦门大学物理系教授
2018年8月-2019年8月：美国华盛顿大学访问教授
2009年8月-2013年6月：新加坡国立大学力学生物研究所，Research Fellow
2006年2月-2009年7月：新加坡国立大学物理系，Research Fellow
2005年3月-2006年1月：新加坡国立大学民用工程系，Research Fellow
2002年9月-2005年2月：新加坡国立大学民用工程系，SMF-Post Doctoral Research Fellow
1998年 9月-2002年7月：清华大学高等研究中心，北京，中国，博士（理论物理）
1993年9月-1998年7月：清华大学物理系，自动化系，北京，中国，理科学士（应用物理），工科学士（计算机应用）

代表性文章或专著

1. Zhang, Z., Y. Zhang, Z. Xue, F. Shang, Y. Liu, S. Le and H. Chen (2026). "Single-molecule magnetic tweezers reveal distinct dynamics and enhanced mechanical stability of ssDNA 31 and 52 knots." Nucleic Acids Res. 54(3): gkag060.

2. Yu, P., Z. Xue, H. Sun, Z. Hou, Z. Zhang, Y. Wang, S. Le and H. Chen (2026). "Harmonizing Competing Intermediates: A Unified Free Energy Landscape of Protein RNase H." Chin. Phys. Lett. 43(2): 020901.

3. Shang, F., Y. Zhang, J. Ye, Z. Zhang, X. Qi, H. Chen, M. Yu and S. Le (2026). "Force-dependent structural dynamics of the giant nesprin-2." Proc Natl Acad Sci U S A 123(4): e2517922123.

4. Zhang, Y., Z. Zhang, H. Sun, Z. Xue, Y. Wang, Z. Guo, S. Le and H. Chen (2025). "Anomalous Force-Dependent Transition Rates Unveil Dual Pathways in Folding and Unfolding Dynamics of Acyl-coenzyme A Binding Protein." Journal of Physical Chemistry Letters 16(10): 2479–2486.

5. Wang, Y., J. Ye, X. Liu, Z. Zhang, F. Shang, X. Qi, Y. Zhang, J. Du, H. Sun, J. Xu, H. Chen, M. Yu and S. Le (2025). "Mechanically weak and highly dynamic state of mechanosensitive titin Ig domains induced by proline isomerization." Nature Communications 16(1): 2771.

6. Hu, D., Y. Wang, H. J. Jiang, H. Pan, Y. Q. Bian, W. T. Ren, H. Chen, Z. L. Guo and Y. W. Wang (2025). "Effect of Additional Terminal Residues on the Folding and Unfolding Dynamics of Cold Shock Protein." Advanced Science: e01369.
   

7. Zhang, Y. H., J. Y. Du, X. Liu, F. Shang, Y. X. Deng, J. Q. Ye, Y. K. Wang, J. Yan, H. Chen, M. Yu and S. M. Le (2024). "Multi-domain interaction mediated strength-building in human a-actinin dimers unveiled by direct single-molecule quantification." Nature Communications 15(1): 6151.

8. Xu, J. S., H. Sun, Z. W. Zhang, Z. L. Guo, S. M. Le and H. Chen (2024). "Folding and Misfolding Dynamics of Irisin Protein Revealed by Single-Molecule Magnetic Tweezers." Journal of Physical Chemistry Letters 15(48): 11954–11960.
   

9. Sun, H., Z. Guo, H. Hong, Z. Zhang, Y. Zhang, Y. Wang, S. Le and H. Chen (2023). "Free Energy Landscape of Type III Fibronectin Domain with Identified Intermediate State and Hierarchical Symmetry." Physical Review Letters 131(21): 218402.

10. Guo, Z. L., H. Y. Hong, G. H. Yuan, H. Qian, B. Li, Y. Cao, W. Wang, C. X. Wu and H. Chen (2020). "Hidden Intermediate State and Second Pathway Determining Folding and Unfolding Dynamics of GB1 Protein at Low Forces." Physical Review Letters 125(19): 198101.
    

11. Yuan, G., S. Le, M. Yao, H. Qian, X. Zhou, J. Yan, and H. Chen. 2017. "Elasticity of the Transition State Leading to an Unexpected Mechanical Stabilization of Titin Immunoglobulin Domains." Angew. Chem. Int. Ed. Engl. 56: 5490-5493.

12. Chen, H., G. Yuan, R. S. Winardhi, M. Yao, I. Popa, J. M. Fernandez, and J. Yan. 2015. "Dynamics of Equilibrium Folding and Unfolding Transitions of Titin Immunoglobulin Domain under Constant Forces." J. Am. Chem. Soc. 137: 3540-3546.

13. Chen, H., H. Fu, X. Zhu, P. Cong, F. Nakamura, and J. Yan. 2011. "Improved high-force magnetic tweezers for stretching and refolding of proteins and short DNA." Biophys. J. 100: 517-523.

    
    

14. Sun, H., S. Le, Z. Guo and H. Chen (2024). Chapter Nine - Exploring the free energy landscape of proteins using magnetic tweezers. Methods in Enzymology. M. Ju Shon and T.-Y. Yoon, Academic Press. 694: 237–261.

15. Guo, Z. L. and H. Chen (2021). Single-Molecule Manipulation by Magnetic Tweezers. Single-Molecule Tools for Bioanalysis. S. Huang, Jenny Stanford Publishing.
    

科研基金及项目

中央高校基本科研业务费（2013-2015）
国家自然科学基金面上项目（2015-2018）(2016-2019)（2019-2022）（2022-2025）（2025-2028）

任教课程

大学物理（大一）
生物物理导论（Introduction to Biophysics，大三）
单分子生物物理（研究生）