DOI number:10.1016/j.bspc.2016.08.022

Journal:Biomedical Signal Processing and Control

Abstract:Gait rhythm disturbances due to abnormal strides indicate the degenerative mobility regulation of motor neurons affected by Parkinson's disease (PD). The aim of this work is to compute the approximate entropy (ApEn), normalized symbolic entropy (NSE), and signal turns count (STC) parameters for the measurements of stride fluctuations in PD. Generalized linear regression analysis (GLRA) and support vector machine (SVM) techniques were employed to implement nonlinear gait pattern classifications. The classification performance was evaluated in terms of overall accuracy, sensitivity, specificity, precision, Matthews correlation coefficient (MCC), and area under the receiver operating characteristic (ROC) curve. Our experimental results indicated that the ApEn, NSE, and STC parameters computed from the stride series of PD patients were all significantly larger (Wilcoxon rank-sum test: p < 0.01) than those of healthy control subjects. Based on the distinct features of ApEn, NSE, and STC, the SVM provided an accuracy rate of 84.48% and MCC of 0.7107, which are better than those of the GLRA (accuracy: 82.76%, MCC: 0.6552). The SVM and GLRA methods were able to distinguish PD gait patterns from healthy control cases with area of 0.9049 (SVM sensitivity: 0.7241, specificity: 0.9655) and 0.9037 (GLRA sensitivity: 0.8276, specificity: 0.8276) under the ROC curve, respectively, which are better or comparable with the classification results achieved by the other popular pattern classification methods.

Co-author:Pinnan Chen,Xin Luo,Meihong Wu,Lifang Liao,Shanshan Yang,Rangaraj M. Rangayyan

First Author:Yunfeng Wu*

Indexed by:Article

Volume:31

Issue:1

Page Number:265-271

Translation or Not:no

Date of Publication:2017-01-01

Included Journals:SCI

Links to published journals:https://doi.org/10.1016/j.bspc.2016.08.022