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中文
Yunfeng Wu

Associate professor

Supervisor of Master's Candidates


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Date of Employment:2009-12-14

School/Department:信息学院

Education Level:博士研究生毕业

Business Address:厦门大学翔安校区西部片区6号楼(睿信楼)202室

Gender:Male

Contact Information:yunfengwu@xmu.edu.cn

Degree:Doctor of Engineering (D.Eng.)

Status:在职

Alma Mater:北京邮电大学

Discipline:生物医学工程
信号与信息处理

Academic Honor:

2013   Outstanding talents in the new century

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Computer-aided analysis of gait rhythm fluctuations in amyotrophic lateral sclerosis

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DOI number:10.1007/s11517-009-0527-z

Journal:Medical & Biological Engineering & Computing

Abstract:Deterioration of motor neurons due to amyotrophic lateral sclerosis (ALS) would affect the strides from one gait cycle to the next. Computer-assisted techniques are useful for gait analysis, and also have high potential in quantitatively monitoring the pathological progression. In this paper, we applied the signal turns count method to measure the fluctuations in the swing-interval time series recorded from 16 healthy control subjects and 13 patients with ALS. The swing-interval turns count (SWITC) parameter derived with the threshold of 0.06 s presented a significant difference (p < 0.001) between the healthy control subjects and ALS patients. Besides the SWITC, we also computed the averaged stride interval (ASI), which is usually longer in the patient with ALS (p < 0.0001), to characterize the gait patterns of ALS patients. In the pattern classification experiments, the Fisher's linear discriminant analysis (FLDA) and the least squares support vector machine (LS-SVM), both input with the SWITC and ASI features, were evaluated using the leave-one-out cross-validation method. The results showed that the LS-SVM with sigmoid kernels was able to provide a classification accurate rate of 89.66% and an area of 0.9629 under the receiver operating characteristic (ROC) curve, which were superior to those obtained with the linear classifier in the form of FLDA.

Co-author:Sridhar Krishnan

First Author:Yunfeng Wu*

Indexed by:Article

Volume:47

Issue:11

Page Number:1165-1171

Translation or Not:no

Date of Publication:2009-11-01

Included Journals:SCI

Links to published journals:https://doi.org/10.1007/s11517-009-0527-z