邓文波教授

所在系部/医院：

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实验室网址：https://crr.xmu.edu.cn/DengLab/index.html

个人简介

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研究领域

主要关注早期妊娠过程中胚胎着床和蜕膜化、分娩启动及其异常的分子机制。妊娠是一个复杂的、受多维因素精确调控的过程，在胚胎与母体子宫的相互作用过程中仍存在很多悬而未决的谜团，如何从不同的方向和维度来厘清这一过程是我们现在所面临的挑战。妊娠成功的母体如何在正确的时间起始分娩及其背后的分子机制现在也尚不明确，由于分娩起始异常可导致早产或者难产，因此，课题组将以生物信息为主要手段，在海量的RNA-Seq、ChIP-Seq、scRNA-Seq，HiC和m6A的数据中，结合多种转基因动物模型挖掘上述生理过程中蕴含的分子调控机制。

学习经历

2001-2005 东北农业大学生命科学院理学学士；

2005-2008 东北农业大学生命科学院理学硕士；

2008-2013 厦门大学生命科学院理学博士；

工作经历

2013~2015 华南农业大学博士后；

2014~2019 美国辛辛那提儿童医院医学中心博士后、Research Associate；

2019~2022 厦门大学医学院副教授；

2022~至今厦门大学医学院教授；

代表性成果

Liu M*, Ji MJ*, Cheng JH, Li Y, Tian YP, Zhao H, Wang Y, Zhu S, Zhang LL, Xu XM, Feng GS, Liang XH, Bao HL, Tang YD, Kong SB, Lu JH, Wang HB#, Lu ZX# and Deng WB#. Deciphering an critical role of uterine epithelial SHP2 in parturition initiation at single cell resolution. Nat Commun, 2023.

Zhao H*, Wang Y*, Xu H*, Liu M, Xu X, Zhu S, Liu Z, Cai H, Wang Y, Lu J, Yang X, Kong S, Bao H#, Wang H#, Deng W#. Stromal cells-specific retinoic acid determines parturition timing at single-cell and spatial-temporal resolution. iScience, 2023

Liu M*, Deng W*, Tang L, Liu M, Bao H, Guo C, Zhang, Lu J, Wang H*, Lu Z*, Kong S*. Menin directs regionalized decidual transformation through epigenetically setting PTX3 as an obstacle balancing FGF and BMP signaling. Nat Commun, 2022.

Huang P, Deng W*, Bao H, Lin Z, Liu M, Wu J, Zhou X, Qiao M, Yang Y, Cai H, Rao F, Chen J, Chen D, Lu J, Wang H, Qin A, Kong S. SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization. Elife. 2022 Mar 4;11:e72073. doi: 10.7554/eLife.72073.

Lv H, Zhao G, Jiang P, Wang H, Wang Z, Yao S, Zhou Z, Wang L, Liu D, Deng W#, Dai J,# Hu Y#. Deciphering the endometrial niche of human thin endometrium at single-cell resolution. Proc Natl Acad Sci U S A. 2022

Du L*, Deng W*, Zeng S, Xu P, Huang L, Liang Y, Wang Y, Xu H, Tang J, Bi S, Zhang L, Li Y, Ren L, Lin L, Deng W, Liu M, Chen J, Wang H, Chen D.Single-cell transcriptome analysis reveals defective decidua stromal niche attributes to recurrent spontaneous abortion. Cell Prolif. 2021

Deng WB*, Yuan J*, Cha JY, Sun XF, Bartos A, Yagita H, Hirota Y, Dey SK. Endothelial cells in the decidual bed are potential therapeutic targets for preterm birth prevention. Cell Reports. 2019 May

Jia Yuan*, Shizu Aikawa*, Wenbo Deng*, Amanda Bartos, Gerd Walz, Florian Grahammer, Tobias B Huber, Xiaofei Sun, Sudhansu K Dey. Primary Decidual Zone Formation Requires Scribble for Pregnancy Success in Mice. Nat Commun, 10(1),5425. 2019 Nov 28.

Shizu Aikawa*, Wenbo Deng*, Xiaohuan Liang, Jia Yuan, Amanda Bartos, Xiaofei Sun, Sudhansu K Dey, Uterine Deficiency of High-Mobility Group box-1 (HMGB1) Protein Causes Implantation Defects and Adverse Pregnancy Outcomes, Cell Death Differ, 2019 Oct 8.

Wei Lei, Tingting Feng, Xing Fang, You Yu, Junjie Yang, Zhen-Ao Zhao, Junwei Liu, Wenbo Deng#, Shijun Hu#. Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes. Stem Cell Res Ther. 2018 Mar 9.

Yuan J*, Wenbo Deng*, Cha J, Xiaofei Sun, Jean-Paul Borg, Dey SK. Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation. Nat Commun. 2018 Feb 9;9(1):603.

Deng WB*, Cha J*, Yuan J, Haraguchi H, Bartos A, Leishman E, Viollet B, Bradshaw HB, Hirota Y, Dey SK. p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing. J Clin Invest. 2016 Aug 1;126(8):2941-54.

Deng WB, Liang XH, Liu JL, Yang ZM. Regulation and function of deiodinases during decidualization in female mice. Endocrinology. 2014. 155(7):2704-17.

Deng WB, Tian Z, Liang XH, Wang BC, Yang F, Yang ZM. Progesterone regulation of Na/K-ATPase β1 subunit expression in the mouse uterus during the peri-implantation period. Theriogenology. 2013. 79(8):1196-203. (F1000Prime Recommended).