发育过程中表观遗传信息通过控制时空特异性基因的有序表达精确调控细胞的命运。本课题组主要研究胚胎发育及胚胎干细胞定向分化过程中基因表达谱重编程的表观遗传调控机理，重点关注增强子、绝缘子等转录调控元件序列在细胞命运决定过程中通过染色质微环境及染色质远程互作对靶基因转录水平的调控作用。通过优化并开发生物信息分析流程提出新的理论模型，采用最新的基因编辑技术并优化多组学文库构建技术对模型进行生物学功能验证，为理解发育及疾病发生等过程中细胞功能特征的转变提出新的思路。

2001~2005 南京农业大学生物技术专业 理学学士；

2005~2012 中国科学院上海生物化学与细胞生物学研究所发育生物学专业   博士；

2012~2013 中国科学院神经科学研究所  助理教授；

2014~2020 美国埃默里大学  博士后研究员；

2020~至今 厦门大学医学院  教授

1.Lyu X*, Rowley MJ, Kulik MJ, Dalton S & Corces VG*. Regulation of CTCF loop formation during pancreatic cell differentiation. Nat Commun. 2023 Oct 9; 14(1): 6314 (一作，共同通讯)

2. Qiu F, Jiang P, Zhang G, An j, Ruan K, Lyu X#, Zhou J#, Sheng W#. Priming with LSD1 inhibitors promotes the persistence and antitumor effect of adoptively transferred T cells. Nat Commun. 2024 May 21; 15:4327 (共同通讯)

3. Klein KN#, Zhao PA#, Lyu X#, Sasaki T, Bartlett DA, Singh AM, Tasan I, Zhang M, Watts LP, Hiraga S, Natsume T, Zhou X, Baslan T, Leung D, Kanemaki MT, Donaldson AD, Zhao H, Dalton S, Corces VG, Gilbert DM. Replication timing maintains the global epigenetic state in human cells. Science. 2021 Apr 23;372(6540):371-378 (共一作，# equal contribution)

4.Lyu X, Rowley MJ, Corces VG. Architectural Proteins and Pluripotency Factors Cooperate to Orchestrate the Transcriptional Response of hESCs to Temperature Stress. Molecular Cell. 2018 Sep 20;71(6):940-955.

5.Li L#, Lyu X#, Hou C#, Takenaka N, Nguyen HQ, Ong CT, Cubeñas-Potts C, Hu M, Lei EP, Bosco G, Qin ZS, Corces VG. Widespread rearrangement of 3D chromatin organization underlies polycomb-mediated stress-induced silencing. Molecular Cell. 2015 Apr 16;58(2):216-31. (共一作，# equal contribution)

6.Lyu X, Corces VG. Engineering 3D genome organization. Cell Research. 2019 Jan;29(1):1-3.

1.     自然科学基金面上项目：异染色质及先锋因子通过干扰染色质环挤压影响hESCs分化过程中增强子的功能，2025至2028，主持

2.  自然科学基金面上项目：染色质高维结构在人胚胎干细胞向胰岛β细胞分化过程中的动态变化，2022-2025，主持

3.     科技部重点研发计划：人类胚胎着床过程中的细胞分化机制研究-课题3：谱系发育异常与胚胎停育及早期流产，2021-2024，骨干

4. 科技部重点研发计划：极早产儿救治和后遗症防治关键技术研究，2023-2025，主持

1. Lyu X*, Rowley MJ, Kulik MJ, Dalton S & Corces VG*. Regulation of CTCF loop formation during pancreatic cell differentiation. Nat Commun. 2023 Oct 9; 14(1): 6314 (一作，共同通讯)

2. Qiu F, Jiang P, Zhang G, An j, Ruan K, Lyu X#, Zhou J#, Sheng W#. Priming with LSD1 inhibitors promotes the persistence and antitumor effect of adoptively transferred T cells. Nat Commun. 2024 May 21; 15:4327 (共同通讯)

3. Klein KN#, Zhao PA#, Lyu X#, Sasaki T, Bartlett DA, Singh AM, Tasan I, Zhang M, Watts LP, Hiraga S, Natsume T, Zhou X, Baslan T, Leung D, Kanemaki MT, Donaldson AD, Zhao H, Dalton S, Corces VG, Gilbert DM. Replication timing maintains the global epigenetic state in human cells. Science. 2021 Apr 23;372(6540):371-378 (共一作，# equal contribution)

4. Yu L, Shen H, Lyu X*. Roles of Polycomb Complexes in the Reconstruction of 3D Genome Architecture during Preimplantation Embryonic Development. Genes. 2022: 13 (12), 2382 (通讯作者)

5. Lyu X, Rowley MJ, Corces VG. Architectural Proteins and Pluripotency Factors Cooperate to Orchestrate the Transcriptional Response of hESCs to Temperature Stress. Molecular Cell. 2018 Sep 20;71(6):940-955.

6. Li L#, Lyu X#, Hou C#, Takenaka N, Nguyen HQ, Ong CT, Cubeñas-Potts C, Hu M, Lei EP, Bosco G, Qin ZS, Corces VG. Widespread rearrangement of 3D chromatin organization underlies polycomb-mediated stress-induced silencing. Molecular Cell. 2015 Apr 16;58(2):216-31. (共一作，# equal contribution)

7. Lyu X, Corces VG. Engineering 3D genome organization. Cell Research. 2019 Jan;29(1):1-3.

8. Xu C#, Lu X#, Chen EZ, He Z, Uyunbilig B, Li G, Ma Y, Hui L, Xie B, Gao Y, Ding X, Hu Y, Hu P*, Han JD*, Wang X. Genome-wide roles of Foxa2 in directing liver specification. Journal of Molecular Cell Biology. 2012 Dec;4(6):420-2. (共一作，#equal contribution; * corresponding authors)

9. Rowley MJ, Lyu X, Rana V, Ando-Kuri M, Karns R, Bosco G, and Corces VG. Condensin II Counteracts Cohesin and RNA Polymerase II in the Establishment of 3D Chromatin Organization. Cell Reports. 2019 Mar12;26:2890–2903.

10. Rowley MJ#, Nichols MH#, Lyu X, Ando-Kuri M, Rivera ISM, Hermetz K, Wang P, Ruan Y, Corces VG. Evolutionarily Conserved Principles Predict 3D Chromatin Organization. Molecular Cell. 2017 Sep 7;67(5):837-852.

11. Cubeñas-Potts C#, Rowley MJ#, Lyu X, Li G, Lei EP, Corces VG. Different enhancer classes in Drosophila bind distinct architectural proteins and mediate unique chromatin interactions and 3D architecture. Nucleic Acids Res. 2017 Feb 28;45(4):1714-1730.

12. Wilson K#, Dileep V#, Marchal C, Lyu X, Li B, Axel P, Bartlett D, Qin Z, Robins AJ, Schulz TC, Corces VG, Gilbert DM. Rapid Irreversible Transcriptional Reprogramming in Human Stem Cells Accompanied by Discordance between Replication Timing and Chromatin Compartment. Stem Cell Reports. 2019 Jul 9;13(1):193-206.

13. Jung Y, Sauria MEG, Lyu X, Cheema MS, Ausio J, Taylor J, Corces VG. Chromatin States in Mouse Sperm Correlate with Embryonic and Adult Regulatory Landscapes. Cell Reports. 2017 Feb 7;18(6):1366-1382.

14. Beagan JA, Gilgenast TG, Kim J, Plona Z, Norton HK, Hu G, Hsu SC, Shields EJ, Lyu X, Apostolou E, Hochedlinger K, Corces VG, Dekker J, Phillips-Cremins JE. Local Genome Topology Can Exhibit an Incompletely Rewired 3D-Folding State during Somatic Cell Reprogramming. Cell Stem Cell. 2016 May 5;18(5):611-24.

15. Jung YH, Gold HB, Kremsky I, Rowley MJ, Punyawai K, Buonanotte A, Lyu X, Bixler BJ, Chan AWS, and Corces VG. Maintenance of CTCF- and transcription factor-mediated interactions from gametes to the early mouse embryo. Molecular Cell. 2019 Jul 11;75(1):154-171.e5.

16. Gutierrez-Perez I#, Rowley MJ#, Lyu X, Valadez-Graham V, Ballesta-Illan E, Lopez-Atalaya JP, Kremsky IJ, Vallejo DM, Caparros E, Corces VG, Dominguez M. Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb. Cell Reports. 2019 Sep 3;28(10):2715-2727.e5.