许韧教授
所在系部/医院：细胞应激生物学国家重点实验室跃进楼A503
办公电话：0592-2880577
电子邮箱：
实验室网址：https://xulab.xmu.edu.cn/index.htm
学术任职
国际华人骨研学会（ICMRS）终身会员、中国医师协会运动医学基础学组委员、中国细胞生物学会发育生物学分会委员、中国生理学会基质生物学专业委员会委员、Annals of Joint期刊执行主编
个人简介
厦门大学-细胞应激生物学国家重点实验室/医学院
国家海外高层次青年人才（中组部）
福建省“杰出青年”
福建省“闽江学者”特聘教授
厦门市“双百计划”高层次创新人才
福建省器官与组织再生重点实验室 主任
厦门大学附属第一医院 特聘主任（骨科与细胞治疗中心）
厦门大学-国际华人骨研学会骨骼干细胞联合研究中心 主任
东京科学大学（原国立东京医科齿科大学）博士，美国康奈尔大学-博士后；研究方向为骨骼干细胞与系统骨骼生物学，以第一(含并列)/通讯作者发表论文于Nature、Nature Medicine、Nature Communications、Advanced Science、Bone Research等权威期刊；作为负责人，主持国家重点研发计划(课题)、国自然重大研究计划(培育)、国自然面上等国家级项目；荣获2019美国John Haddad 青年学者奖（全球10人）、2023-COA骨科基础研究青年学者奖（第一名；1/123）等国内外学术奖项；担任Bone Research、Bone、Journal of Orthopaedic translation等骨科专业杂志的编委，受Lancet、eLife、Protein & Cell等国际知名期刊邀请撰写论述性文章。
研究领域
聚焦于骨形成干/祖细胞及其支撑系统的调控机制，深入探究靶向成骨微环境的临床潜能。
当前主要研究方向如下：
1.骨特异性神经/血管体系在退行性疾病中的作用机制
2.骨骼干细胞/前体细胞亚型的鉴定及其分化等级归属
3.骨形成细胞因子在机体代谢类疾病中的系统学功能
学习经历
2008.9-2013.3 日本（国立）东京医科齿科大学 外科学专业 博士
2005.9-2008.6 厦门大学 微生物学专业 硕士
2001.9-2005.6 安徽师范大学 生物工程专业 学士
工作经历
2019-至今 厦门大学医学院 教授；
2014-2019 美国康奈尔大学威尔医学院 博士后；
2013-2014 日本（国立）东京医科齿科大学 博士后。
代表性成果
代表性成果（* 通讯；# 并列第一）
(1) Weinan Cheng, Jianming Huang, Na Li, Ren Xu*. Skeletal stem-cell
therapy: challenge meets opportunity, Lancet, 2024, Jan 20; 403 (10423):243.
(2) Zan Li#; Baohong Shi#; Na Li#; Jun Sun; Xiangchen Zeng; Rui Huang; Seoyeon Bok; Xiaohui Chen; Jie Han; Alisha R. Yallowitz; Shawon Debnath; Michelle Cung; Zheng Ling; Chuan-Qi Zhong; Yixang Hong; Gang Li; Mascha Koenen; Paul Cohen; Xinhui Su; Hongbin Lu; Matthew B. Greenblatt; Ren Xu*; Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion, Nature Communications, 2024, 15(1): 6697
(3) Na Li#; Baohong Shi#; Zan Li; Jie Han; Jun Sun; Haitao Huang; Alisha R Yallowitz; Seoyeon Bok; Shuang Xiao; Zuoxing Wu; Yu Chen; Tian Qin; Rui Huang; Haiping Zheng; Rong Shen; Lin Meng; Matthew B Greenblatt; Ren Xu*; Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta, Bone Research, 2024, 12(1): 46（封面文章）
(4) Yu Chen#, Zhang Long#, Xueqing Shi#, Jie Han, Jingyu Chen, Xinya Zhang, Danlin Xie, Zan Li, Xing Niu, Lijie Chen, Chaoyong Yang, Xiujie Sun, Taifeng Zhou, Peiqiang Su, Na Li, Matthew B. Greenblatt, Rongqin Ke*, Jianming Huang*, Zhe-Sheng Chen*, Ren Xu*. Characterization of the Nucleus Pulposus Progenitor Cells via Spatial Transcriptomics, Advanced Science, 2024, 2303752
(5) Xie Chunlan#, Yue Yuting#, Xu Jingping, Li Na, Lin Ting, Ji Guangrong*, Yang Xianwen*, Xu Ren*. Penicopeptide A (PPA) from the deep-sea-derived fungus promotes osteoblast-mediated bone formation and alleviates ovariectomy-induced bone loss by activating the AKT/GSK-3β/β-catenin signaling pathway, Pharmacological Research, 2023, 197:106968
(6) Sun Jun#, Shin Dongyeon#, Eiseman Mark, Yallowitz AlishaR, Li Na, Lalani Sarfaraz, Li Zan, Cung Michelle, Bok Seoyeon, Debnath Shawon, Marquez Ssofia Jenia, White Tommy E., Khan Abdul G., Lorenz Ivo C., Shim Jae-Hyuck, Lee Francis S., Xu Ren*, Greenblatt Matthew B.* SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts, Nature Communications, 2021, 12(1):4611
(7) Na Li#, Kazuki Inoue#, Jun Sun, Yingzhen Niu, Sarfaraz Lalani, Alisha Yallowitz, Xu Yang, Chao Zhang, Rong Shen, Baohong Zhao, Ren Xu*, Matthew B. Greenblatt. Osteoclasts are not a source of SLIT3, Bone Research, 2020, 8(1):11
(8) Ren Xu , Alisha Yallowitz, An Qin, Zhuhao Wu, Dong Yeon Shin, Jung-Min Kim, Shawon Debnath, Gang Ji, Mathias P. Bostrom, Xu Yang, Chao Zhang, Han Dong, Pouneh Kermani, Sarfaraz Lalani, Na Li, Yifang Liu, Michael G. Poulos1, Amanda Wach, Yi Zhang, Kazuki Inoue, Annarita Di Lorenzo, Baohong Zhao, Jason M. Butler, Jae-Hyuck Shim, Laurie H. Glimcher*, Matthew B. Greenblatt*, Targeting skeletal endothelium to ameliorate bone loss, Nature Medicine, 2018, 24(6):823-833
(9) Toru Fukuda#, Shu Takeda#*, Ren Xu#, Hiroki Ochi, Satoko Sunamura, Tsuyoshi Sato, Shinsuke Shibata, Yutaka Yoshida, Zirong Gu, Ayako Kimura, Chengshan Ma, Cheng Xu, Waka Bando, Koji Fujita, Kenichi Shinomiya, Takashi Hirai, Yoshinori Asou, Mitsuhiro Enomoto, Hideyuki Okano, Atsushi Okawa,Hiroshi Itoh, Sema3A regulates bone-mass accrual through sensory innervations. Nature, 2013,497(7450):490-3
主持课题
1. 国家自然科学基金面上项目，Schnurri-3在骨调控机体能量代谢中的作用机制研究，82372362，2024-01至2027-12，主持；
2. 科技部国家重点研发计划干细胞及转化研究项目，间充质干细胞新功能性亚群的鉴定及调控机制，2020YFA0112901，2020-10至2024-12，主持；
3. 国家自然科学基金重大研究计划（培育项目），SLIT2介导的神经嵌入在骨骼干细胞命运归属和成骨化进程中的作用机制研究，92068104，2020-01至2023-12，主持；
4. 国家自然科学基金面上项目，SLIT3介导的血管亚型在骨骼干细胞微环境中的作用机制研究，81972034，2020-01至2023-12，主持；
5. 福建省自然科学基金杰出青年基金项目，骨骼干细胞的神经纤维微环境及其调控机制，2022J06003，2022-08至2025-08，主持
获奖及荣誉
1. John Haddad Young Investigator Award，2019年
2. 中华医学会骨科学分会（COA）骨科基础青年研究奖一等奖
所有论文列表
1. Weinan Cheng, Jianming Huang, Na Li, Ren Xu* , Skeletal stem-cell therapy: challenge meetsopportunity, Lancet, 2024, 403(10423): 243.
2. Guixin Yuan#, Xixi Lin#, Ying Liu#, Matthew B. Greenblat*, Ren Xu*, Skeletal stem cells in bone development, homeostasis, and disease, Protein & Cell, 2024, DOI10.1093/procel/pwae008
3. Yu Chen#, Zhang long#, Xueqing Shi#, Jie Han, Jingyu Chen, Xinya Zhang, Danlin Xie, Zan Li, Xing Niu, Lijie Chen, Chaoyong Yang, Xiujie Sun, Taifeng Zhou, Peiqiang Su, Na Li, Matthew B. Greenblatt, Rongqin Ke*, Jianming Huang*, Zhe-Sheng Chen*, Ren Xu*. Characterization of the Nucleus Pulposus Progenitor Cells via Spatial Transcriptomics, Advanced Science, 2024, doi/10.1002/advs.202303752
4. Zan Li#, Xiangchen Zeng#, Baohong Shi#, Jie Han, Zuoxing Wu,
4.Xiaohui Chen, Long Zhang, Na Li, Matthew Greenblatt, Jianming Huang*, Ren Xu*. Schnurri-3 controls osteogenic fate of Adipoq-lineage progenitors in bone marrow, Journal of Orthopaedic Translation, 2024, 45:168-177
5. Chun-Lan Xie#, Yu-Ting Yue#, Jing-Ping Xu, Na Li Ting Lin, Guang-Rong Ji*, Xian-Wen Yang*, Ren Xu*. Penicopeptide A (PPA) from the deep-sea-derived fungus promotes osteoblast-mediated bone formation and alleviates ovariectomy-induced bone loss by activating the AKT/GSK-3β/β-catenin signaling pathway. Pharmacological Research, 2023, 197:106968
6. Long Zhang, Na Li, Ren Xu*. Where it all started. eLife, 2023, 12: e87355
7. Taifeng Zhou#, Yu Chen#, Zhiheng Liao#, Long Zhang, Deying Su, Zhuling Li, Xiaoming Yang, Xiaona Ke, Hengyu Liu, Yuyu Chen, Ricong Weng, Huimin Shen, Caixia Xu, Yong Wan, Ren Xu*, Peiqiang Su*. Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single-Cell Resolution. Advanced Science, 2023, 10(14):2206296
8. Yingwen Chen, Xuanqun Wang, Xing Na, Yingkun Zhang, Zan Li, Xiaohui Chen, Linfeng Cai, Jia Song, Ren Xu*, Chaoyong Yang*. Highly Multiplexed, Efficient, and Automated Single-Cell MicroRNA Sequencing with Digital Microfluidics. Small Methods, 2023, 8(3), DOI10.1002/smtd.202301250
9. Jun Sun#, Dong Yeon Shin#, Mark Eiseman, Alisha R. Yallowitz, Na Li, Sarfaraz Lalani, Zan Li, Michelle Cung, Seoyeon Bok, Shawon Debnath, Sofia Jenia Marquez, Tommy E. White, Abdul G. Khan, Ivo C. Lorenz, Jae-Hyuck Shim, Francis S. Lee, Ren Xu*, Matthew B. Greenblatt*. SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts, Nature Communications, 2021, 12(1):4611
10. Na Li#, Kazuki Inoue#, Jun Sun, Yingzhen Niu, Sarfaraz Lalani, Alisha Yallowitz, Xu Yang, Chao Zhang, Rong Shen, Baohong Zhao, Ren Xu*, Matthew B. Greenblatt. Osteoclasts are not a source of SLIT3, Bone Research, 2020, 8(1):11
11. Ren Xu , Alisha Yallowitz, An Qin, Zhuhao Wu, Dong Yeon Shin, Jung-Min Kim, Shawon Debnath, Gang Ji, Mathias P. Bostrom, Xu Yang, Chao Zhang, Han Dong, Pouneh Kermani, Sarfaraz Lalani, Na Li, Yifang Liu, Michael G. Poulos1, Amanda Wach, Yi Zhang, Kazuki Inoue, Annarita Di Lorenzo, Baohong Zhao, Jason M. Butler, Jae-Hyuck Shim, Laurie H. Glimcher*, Matthew B. Greenblatt*, Targeting skeletal endothelium to ameliorate bone loss, Nature Medicine, 2018, 24(6):823-833
12. Toru Fukuda#, Shu Takeda#*, Ren Xu#, Hiroki Ochi, Satoko Sunamura, Tsuyoshi Sato, Shinsuke Shibata, Yutaka Yoshida, Zirong Gu, Ayako Kimura, Chengshan Ma, Cheng Xu, Waka Bando, Koji Fujita, Kenichi Shinomiya, Takashi Hirai, Yoshinori Asou, Mitsuhiro Enomoto, Hideyuki Okano, Atsushi Okawa,Hiroshi Itoh, Sema3A regulates bone-mass accrual through sensory innervations. Nature, 2013,497(7450):490-3.
