阿尔茨海默病（Alzheimer’s Disease, AD）俗称老年性痴呆，是最为常见的神经退行性疾病。目前该疾病的致病机制还处于系列假说中，临床上更是缺少有效防治药物。我们实验室当前主要致力于以下几个研究方向：

1. 小胶质细胞的生理及病理功能，揭示其在AD发生发展中的作用;

2. 阐述TREM2基因突变如何增加AD患病风险;

3. 免疫相关补体蛋白在AD中的作用及机制。

2006~2010 东华理工大学生物技术专业  理学学士

2010~2015 厦门大学生理学专业        理学博士

2016~2019 厦门大学医学院  博士后

2019~2021 厦门大学医学院  助理教授

2021~至今 厦门大学医学院  副教授

1.Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, Wang D, Gao Y, Zhu Y, Sheng X, Chen K, Wang N, Zhu L, Can D, Marten Y, Shinohara M, Liu C C, Du D, Sun H, Wen L, Xu H, Bu G, Chen X F. Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model[J]. Nat Commun 2019;10 (1):1365.

(Selected in Nat Commun “Editors' Highlights”; Selected in “Spotlight” by Alzforum)

2.Zhong L, Wang Z, Wang D, Wang Z, Martens Y A, Wu L, Xu Y, Wang K, Li J, Huang R, Can D, Xu H, Bu G, Chen X F. Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)[J]. Mol Neurodegener 2018;13 (1):15.

3.Zhong L, Zhang Z L, Li X, Liao C, Mou P, Wang T, Wang Z, Wang Z, Wei M, Xu H, Bu G, Chen X F. TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway[J]. Front Aging Neurosci 2017;9:204.

4.Zhong L, Chen X F, Wang T, Wang Z, Liao C, Wang Z, Huang R, Wang D, Li X, Wu L, Jia L, Zheng H, Painter M, Atagi Y, Liu C C, Zhang Y W, Fryer J D, Xu H, Bu G. Soluble TREM2 induces inflammatory responses and enhances microglial survival[J]. J Exp Med 2017;214 (3):597-607.

(Selected for “Best of JEM 2017”; Recommended in F1000Prime; Highlighted by Sci Signal; Highlighted in Alzforum)

5.Zhong L, Xie YZ, Cao TT, Wang Z, Wang T, Li X, Shen RC, Xu H, Bu G, Chen XF: A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism. Mol Neurodegener, 2016, 11:2

6.Zhong L, Chen X F, Zhang Z L, Wang Z, Shi X Z, Xu K, Zhang Y W, Xu H, Bu G. DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response. J Biol Chem, 2015;290 (25):15866-15877.

1. 第60批中国博士后科学基金面上资助一等资助（8万）；

2. 第10批中国博士后科学基金特别资助（15万）；

3. 国家自然科学基金青年项目（20万）；

4. 启动经费（50万）；

https://www.ncbi.nlm.nih.gov/pubmed?term=((Zhong%20Li%5BAuthor%5D)%20AND%20Institute%20of%20Neuroscience%5BAffiliation%5D)%20AND%20Xiamen%20University%5BAffiliation%5D