1. CORNEAL AND OCULAR SURFACE DISEASES, INCLUDING BASIC RESEARCH ON OCULAR STEM CELLS.

2. CORNEAL TISSUE ENGINEERING.

3. RESEARCH ON THE MECHANISM OF OCULAR SURFACE DAMAGE CAUSED BY ENVIRONMENTAL POLLUTANTS.

4. NEW MATERIALS TREAT EYE-RELATED DISEASES.

2000-2004 Undergraduate, School of Life Sciences, Northeast Normal University

2004-2007 Master of Cell Biology, School of Life Sciences, Xiamen University

2007-2010 PhD in Cell Biology, School of Life Sciences, Xiamen University

2011.02-2014.07: Assistant Professor, Eye Institute of Xiamen University.

2015.09-2015.12: Visiting Scholar, University of Kentucky.

2015.12-2016.09: Visiting Scholar, University of Cincinnati.

2014.08-2021.07: Associate Professor, Eye Institute of Xiamen University.

2021.08-present: Professor, Eye Institute of Xiamen University.

1. National Natural Science Foundation of China, 82271045, Research on the role and mechanism of six compound combinations in treating limbal stem cell dysfunction, 2023/01-2026/12, 520,000.

2. National Natural Science Foundation of China General Project, 82070931, Study on the role and mechanism of m6A methyltransferase Mettl3 in corneal squamous metaplasia, 2021/01-2024/12, 550,000.

3. National Natural Science Foundation of China General Project, 81100639, Research on the role and mechanism of autophagy in corneal endothelial damage, 2018/01-2021/12, 560,000.

4. National Natural Science Foundation of China, 81470601, Research on the mechanism of Brd4 regulating corneal epithelial stem cells, 2015/01-2018/12, 730,000.

5. National Natural Science Foundation of China Youth Project, 81770891, functional study of Hif-1α in ocular surface squamous metaplasia, 2012/01-2014/12, 230,000.

6. China Translational Medicine Youth Fund Project, 2017-A-001, Development and application of plant-derived tissue engineering corneal epithelial vectors, 2017/07-2020/06, 300,000.

7. Xiamen Joint Research Project on Important Major Diseases, 3502Z20159017, clinical research on early and accurate diagnosis and rapid reconstruction of chemical eye injuries, 2016/01-2018/12, 200,000.

8. Xiamen University "Life Science and Human Health Discipline Cluster" Discipline Development Project, Research on the role and mechanism of PKHD1 gene in the occurrence of iris-corneal endothelial syndrome, 2019/01-2020/12, 400,000, host

9. Xiamen University President’s Fund Project, Research on the function of Brd4 in the occurrence of ocular surface LSCD, 2015/01-2016/12, 500,000, chaired

10. Fujian Provincial Natural Science Foundation General Project, 2016J01416, Research on the mechanism of bromodomain protein 4 regulating limbal stem cells, 2015/04-2018/04, 40,000.

1.2023 Xiamen University “Dabeinong Scholarship”

2. 2022 Xiamen Science and Technology Progress First Prize, Innovation and Application of Dry Eye Diagnosis and Treatment Technology, 3rd Completer

3. 2020 Xiamen University “Mindu & International Bank Teaching Scholarship”

4. 2020 Fujian Medical Science and Technology Award Second Prize, Basics and Clinical Application of Tissue Engineering Corneal Epithelium, 4th Completer

5. First Prize of Xiamen Science and Technology Progress Award in 2019, Basic Research and Clinical Application of Tissue Engineering Corneal Epithelium, 3rd Completer

6. 2018 First Prize of Fujian Province Science and Technology Progress Award, Research on the Pathogenesis of Dry Eye and Creation and Application of Diagnosis and Treatment System, 5th Completer

7. Outstanding Paper Award at the 2018 Chinese Corneal Disease Academic Conference

8. 2017 Fujian Provincial Science and Technology Progress Third Prize, innovative theory and key technology research on ocular surface and corneal diseases, 3rd completer

9. Second Prize of Xiamen Science and Technology Progress Award in 2017, key technologies and clinical applications for the diagnosis and treatment of corneal and conjunctival diseases, 6th completer

10. 2016 Third Prize of China Medical Science and Technology Award, Key Technologies and Clinical Applications in Diagnosis and Treatment of Ocular Surface Diseases, 4th Completer

11. 2013 First Prize of Fujian Province Science and Technology Progress Award, Series Research and Clinical Application of New Technologies for Corneal Disease Diagnosis and Treatment, 4th Completer

12. First Prize of Xiamen Science and Technology Progress Award in 2013, series research and clinical application of new technologies for corneal disease diagnosis and treatment, 4th completer

13. 2014 Second Prize of Fujian Province Science and Technology Progress Award, Basic Research and Clinical Application of Eye Tissue Bank, 3rd Completer

14. 2014 Xiamen Science and Technology Progress Second Prize, Basic Research and Clinical Application of Eye Tissue Bank, 3rd Completer

15. 2014 Japan Ophthalmology Annual Meeting, travel grant

16. The 9th International Ophthalmology Forum in 2013, travel grant

17. 2012 American Ophthalmology and Vision Science Research Annual Meeting, travel grant

18. Outstanding Paper Award of the 3rd Chinese Ophthalmology Young and Middle-aged Forum in 2011

1.     Fan K, Yu L, Wu Y, Zheng L, Yang X, Lin J, Wang M, Ye Y, Lin R, Chen Q, Liu Z, Xue Y*, Xie J*, Li C*. Clickable corneal neovascularization therapy with ROS-responsive polydopamine silica nanoparticles loaded with fenofibrate.  Author links open overlay panel. Materials & Design, 2023, Oct 235: 112412.

2.     Han Y#, Zheng L#, Wang Y, Fan K, Guo S, Kang H, Lin J, Xue Y*, Liu Z*,Li C*. Corneal stromal filler injection of gelatin-based photocurable hydrogels for maintaining the corneal thickness and reconstruction of corneal stroma. Composites Part B, 2023, Nov 266; 111004.

3.     Wang G#, Xu L#, Shi R, Ye Y, Zeng B, Yang X, Liu Z, Liu Z, Wang S*, Xue Y*, Li C*. Organotypic culture model of mouse meibomian gland as a screening platform for risk factors related to meibomian gland dysfunction. Ocul Surf. 2023 Aug 22;30:73-84. doi: 10.1016/j.jtos.2023.08.007.

4.     Xu L#, Wang G#, Shi R, Zeng B, Zhang Y, Liu Z, Wang S*, Li C*. A Cocktail of Small Molecules Maintains the Stemness and Differentiation Potential of Conjunctival Epithelial Cells. Ocul Surf, 2023 Aug 25;30:107-118. doi: 10.1016/j.jtos.2023.08.005.

5.     Han Y#, Guo S#, Li Y#, Li J, Zhu L, Liu Y, Lv Y, Yu D, Zheng L, Huang C, Li C*, Hu J*, Liu Z*. Berberine ameliorate inflammation and apoptosis via modulating PI3K/AKT/NFκB and MAPK pathway on dry eye. Phytomedicine. 2023 Sep, 155081. doi: 10.1016/j.phymed.2023.155081.

6.     Yang D, Han Y, Wang Y, Pan Y, Zheng L, Liu Z*, Li C*, Wu Y*, Li H*. Highly effective corneal permeability of reactive oxygen species-responsive nano-formulation encapsulated cyclosporine a for dry eye management. Chem Eng J. 2023; 469: 143968.

7.     Kang H, Han Y, Jin M, Zheng L, Liu Z, Xue Y*, Liu Z*, Li C*. Decellularized squid mantle scaffolds as tissue-engineered corneal stroma for promoting corneal regeneration. Bioeng Transl Med. 2023;e10531.

8.     Xu L, Hou S, Huang X, Wang M, Li C*, Dong N*, Lin Z*. Highly sensitive homogeneous electrochemiluminescence biosensor for microRNA-155 based on enzyme-free cascade signal amplification and magnetic assisted enrichment. J  Elec Chem. 2023, 933: 117274.

9.     Tang Y#, Han Y#, Zhao J, Lv Y, Fan C, Zheng L, Zhang Z, Liu Z*, Li C*, Lin Y*. A Rational Design of a Metal-Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns. Nanomicro Lett. 2023 Apr 30;15(1):112.

10.  Bao X, Zhong Y, Yang C, Chen Y, Han Y, Lin X, Huang C, Wang K*, Liu Z*, Li C*. T-Cell Repertoire Analysis in the Conjunctiva of Murine Dry Eye Model. Invest Ophthalmol Vis Sci. 2023 Mar 1;64(3):14.

11.  Zheng L#, Han Y#, Ye E, Zhu Q, Loh X, Li Z* Li C*. Recent Advances in Ocular Therapy by Hydrogel Biomaterials. World Scientific Annual Review of Functional Materials. 2022: 2230002.

12.  Wang Y#, Kang H#, Jin M, Wang G, Ma W, Liu Z, Xue Y*, Li C*. Phenotypic and Transcriptomics Analyses Reveal Underlying Mechanisms in a Mouse Model of Corneal Bee Sting. Toxins (Basel). 2022 Jul 8;14(7):468.

13.   Mei S, Lin J, Liu Z*, Li C*. A Novel Mutation in the FYCO1 Gene Causing Congenital Cataract: Case Study of a Chinese Family. Dis Markers. 2022 Aug 26;2022:5838104.

14.  Zhong Y#, Fang X#, Wang X, Lin Y, Wu H*, Li C*. Effects of Sodium Hyaluronate Eye Drops With or Without Preservatives on Ocular Surface Bacterial Microbiota. Front Med. 2022 Feb 14;9:793565.

15.  Wang X, Zhong Y, Liang M, Lin Z, Wu H*, Li C*. Crosslinking-Induced Corneal Endothelium Dysfunction and Its Protection by Topical Ripasudil Treatment. Dis Markers. 2022 Jan 13;2022:5179247.

16.  Li W, Li X, Cui F, Xu Z, Dong N*, Li C*. The Ocular Surface Characteristics in Prostate Cancer Patients Treated with Androgen Deprivation Therapy. Dis Markers. 2021 Nov 9;2021:5390195.

17.  Zong R, Zhu F, Han W, Wang Y, Wang G, Wang Y, Mao Y, Guan T, Liu Z, Xue Y*, Li C*. Tear dynamics testing and quantitative proteomics analysis in patients with chronic renal failure. J Proteomics. 2021 Aug 16:104351.

18.  Wang G，An X，Jin M, Wang X, Zong R, Liu Z, Liu Z, Xue Y*, Li C*. Real-time confocal microscopy imaging of corneal cytoarchitectural changes induced by different stresses. Exp Eye Res. 2021 Sep;210:108706.

19.  Li Z, Liu M, Ke J, Wang J, Wu C, Li C*, Li Z*, Wu Y*. Flexible polymeric nanosized micelles for ophthalmic drug delivery: research progress in the last three years. Nanoscale Adv. 2021, 3 (18) , 5240-5254.

20.  Han Y#, Jiang L#, Shi H#, Xu C, Liu M, Li Q, Zheng L, Chi H, Wang Y, Liu Z, You M, Loh X, Wu Y*, Li Z*, Li C*. Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye. Bioact Mater. 2021 Jul 28;9:77-91.

21.  Jin M, Wang Y, An X, Kang H, Wang Y, Wang G, Gao Y, Wu S, Reinach P, Liu Z, Xue Y, Li C*. Phenotypic and transcriptomic changes in the corneal epithelium  following exposure to cigarette smoke. Environ Pollut. 2021 Oct 15;287:117540.

22.  An X, Wang G, Jin M, ZhouX, Gao S, Chen J, Reinach P, Liu Z, Xue Y*, Li C*. Novel Cell Culture Paradigm Prolongs Mouse Corneal Epithelial Cell Proliferative Activity in vitro and in vivo. Front Cell Dev Biol. 2021 Jun 30; 9:675998.

23.  Han Y#, Xu C#, Shi H#, Yu F, Zhong Y, Liu Z, Loh X, Wu Y*, Li Z*, Li C*. Engineered bio-adhesive polyhedral oligomeric silsesquioxane hybrid nanoformulation of amphotericin B for prolonged therapy of fungal keratitis. Chem Eng J. 2021, 421, 129734.

24.  Dong N#*, Cai Q#, Li Z, Xu L, Wu H, Lin Z, Qiu B, Li C*, Lin Z*. Convenient hyaluronidase biosensors based on the target-trigger enhancing of the permeability of a membrane using an electronic balance as a readout. Analyst. 2021 May 17;146(10):3299-3304.

25.  Tao Y, Luo F, Lin Y, Dong N*, Li C*, Lin Z*. Quantitative gold nanorods based photothermal biosensor for glucose using a thermometer as readout. Talanta. 2021 Aug 1;230:122364.

26.  Li X#, Wang X#, Wang Y, Wu H*, Li C*. Effect of Proparacaine Hydrochloride Eye Drops on the Ocular Surface. International Journal of Ophthalmology & Visual Science. 2021; 6(1): 46-53.

27.  Ma W, Wang G, Li X, Wu H, Liu Z, Dong N*, Li C*. Study of Factors Influencing Dry Eye in Rheumatoid Arthritis. J Ophthalmol. 2020 Aug 8;2020:5768679.

28.  Wang G, Chen P, Wang Y, Wang Y, Reinach PS, Xue Y, Liu Z*, Li C*. Onion Epithelial Membrane Scaffolds Transfer Corneal Epithelial Layers in Reconstruction Surgery. Adv Healthc Mater. 2020 Jul;9(14):e2000469.

29.  Jin M, Wang Y, Wang Y, Li Y, Wang G, Liu X, Xue Y*, Liu Z, Li C*. Protective effects on corneal endothelium during intracameral irrigation using N-(2)-L-alanyl-L-glutamine. Front Pharmacol. 2020 Mar 27;11:369.

30.   Wang Y, Zhang Y, Lin Z, Wu H*, Li C*. Case Studies of Mycobacterium abscess Infection after Laser in Situ Keratomileusis. Case Reports in Clinical Medicine, 2019 Dec；8(12): 307-314.

31.  Han Y#, Li C#*, Cai Q, Bao X, Tang L, Ao H, Liu J, Jin M, Zhou Y, Wan Y, Liu Z*. Studies on bacterial cellulose/poly vinyl alcohol (BC/PVA) hydrogel composites as tissue-engineered corneal stroma. Biomed Mater. 2020 Apr 30;15(3):035022.

32.  Wang G, Xue Y, Wang Y, Dong F, Shen M, Zong R, Liu Z*, Li C*. The role of autophagy in the pathogenesis of exposure keratitis. J Cell Mol Med. 2019 Jun;23(6):4217-4228.

33.  Yang Q, Tang L, Shen M, Wang Y, Wei Y, Jeyalatha V, Chen P, Dong F, Wang G, Wu S, Liu Z*, Li C*. Effects of diesel exhaust particles on the condition of mouse ocular surface. Ecotoxicol Environ Saf. 2018 Nov 15;163:585-593.

34.  Wang G, Dong N, Wang Y, Li J, Dong F, Jeyalatha V, Wu J, Shen M, Yang Q, Chen P, Xue Y, Liu Z, Li C*. Epithelial dysplasia in pterygium postoperative granuloma. Exp Eye Res. 2018 Oct;175:199-206.

35.  Li J#, Li C#, Wang G, Liu Z, Chen P, Yang Q, Dong N, Wu H, Liu Z*, Li W*. APR-246/PRIMA-1Met Inhibits and Reverses Squamous Metaplasia in Human Conjunctival Epithelium. Invest Ophthalmol Vis Sci. 2016 Feb;57(2):444-52.

36.  Li C, Dong N, Wu H, Dong F, Xu Y, Du H, He H, Liu Z*, Li W*. A novel method for preservation of human corneal limbal tissue. Invest Ophthalmol Vis Sci. 2013 Jun 10;54(6):4041-7.

37.  Li C, Dong F, Jia Y, Du H, Dong N, Xu Y, Wang S, Wu H, Liu Z*, Li W*. Notch signal regulates corneal endothelial-to-mesenchymal transition. Am J Pathol. 2013 Sep;183(3):786-95.

38.  Li C, Yin T, Dong N, Dong F, Fang X, Qu YL, Tan Y, Wu H, Liu Z*, Li W*. Oxygen tension affects terminal differentiation of corneal limbal epithelial cells. J Cell Physiol. 2011 Sep;226(9):2429-37.

39.  Dong N, Qin W, Xue Y, Li C*, Liu Z*. Hypoxia affects in vitro proliferation and differentiation of mouse corneal epithelial progenitor cell. In Vitro Cell Dev Biol Anim. 2013, 49(7), 508-514.

40.  Dong N#, Li C#, Chen W, Qin W, Xue Y, Wu H, Fibrin glue-assisted for the treatment of corneal perforations using glycerin-cryopreserved corneal tissue, Int J Ophthalmol, 2014, 7(1), 62-65.