1、角膜和眼表面疾病，包括眼部干细胞的基础研究。

2、角膜组织工程。

3、环境污染物损伤眼表机制研究。

4、新材料治疗眼部相关疾病。

2000-2004 东北师范大学生命科学学院 本科

2004-2007 厦门大学生命科学学院  细胞生物学硕士

2007-2010 厦门大学生命科学学院  细胞生物学博士

2011.02-2014.07 厦门大学医学院 助理教授

2015.09-2015.12 肯塔基大学药学院 访问学者

2015.12-2016.09 辛辛那提大学医学院 访问学者

2014.08-2021.07 厦门大学医学院 副教授

2021.08~至今 厦门大学医学院 教授

1.国家自然科学基金面上项目，82271045 ,六化合物组合在治疗角膜缘干细胞功能障碍中的作用及机制研究，2023/01-2026/12，52万。

2.国家自然科学基金面上项目，82070931，m6A甲基转移酶Mettl3在角膜鳞状上皮化生中的作用及机制研究，2021/01-2024/12，55万。

3.国家自然科学基金面上项目，81100639，自噬在角膜内皮损伤中的作用及机制研究，2018/01-2021/12，56万。

4.国家自然科学基金面上项目，81470601，Brd4调控角膜上皮干细胞的机理研究，2015/01-2018/12，73万。

5.国家自然科学基金青年项目，81770891，Hif-1α在眼表鳞状上皮化生中的功能研究，2012/01-2014/12，23万。

6.华夏转化医学青年基金项目，2017-A-001，植物源性组织工程角膜上皮载体的开发与应用，2017/07-2020/06，30万。

7.厦门市重要重大疾病联合攻关项目，3502Z20159017，眼化学伤的早期精准诊断与快速重建的临床研究，2016/01-2018/12，20万。

8.厦门大学“生命科学与人类健康学科群”学科发展项目，PKHD1基因在虹膜-角膜内皮综合征发生中的作用及机制研究，2019/01-2020/12，40万，主持

9.厦门大学校长基金项目，Brd4在眼表LSCD发生中功能研究，2015/01-2016/12，50万，主持

10.福建省自然科学基金面上项目，2016J01416，溴基结构域蛋白4调控角膜缘干细胞的机理研究，2015/04-2018/04，4万。

1.2023年厦门大学“大北农奖教金”

2. 2022厦门市科技进步一等奖，干眼诊疗技术创新与应用，第3完成人

3. 2020年厦门大学“闽都&国际银行奖教金”

4. 2020年福建医学科技奖二等奖，组织工程角膜上皮的基础和临床应用，第4完成人

5. 2019年厦门市科技进步一等奖，组织工程角膜上皮的基础研究和临床应用，第3完成人

6. 2018年福建省科技进步一等奖，干眼发病机制的研究及诊疗体系的创立与应用，第5完成人

7. 2018年中国角膜病学术会议优秀论文奖

8. 2017年福建省科技进步三等奖，眼表与角膜病的创新理论和关键技术研究，第3完成人

9. 2017年厦门市科技进步二等奖，角结膜疾病诊治关键技术及临床应用，第6完成人

10. 2016年华夏医学科技奖三等奖，眼表疾病诊疗的关键技术与临床应用，第4完成人

11. 2013年福建省科技进步一等奖，角膜病诊断与治疗新技术的系列研究与临床应用，第4完成人

12. 2013年厦门市科技进步一等奖，角膜病诊断与治疗新技术的系列研究与临床应用，第4完成人

13. 2014年福建省科技进步二等奖，眼组织库的基础研究及临床应用，第3完成人

14. 2014年厦门市科技进步二等奖，眼组织库的基础研究及临床应用，第3完成人

15. 2014年日本眼科年会，travel grant

16. 2013年第九届国际眼科论坛，travel grant

17. 2012年美国眼科与视觉科学研究年会，travel grant

18. 2011年第三届中华眼科中青年论坛优秀论文奖

1.     Fan K, Yu L, Wu Y, Zheng L, Yang X, Lin J, Wang M, Ye Y, Lin R, Chen Q, Liu Z, Xue Y*, Xie J*, Li C*. Clickable corneal neovascularization therapy with ROS-responsive polydopamine silica nanoparticles loaded with fenofibrate.  Author links open overlay panel. Materials & Design, 2023, Oct 235: 112412.

2.     Han Y#, Zheng L#, Wang Y, Fan K, Guo S, Kang H, Lin J, Xue Y*, Liu Z*,Li C*. Corneal stromal filler injection of gelatin-based photocurable hydrogels for maintaining the corneal thickness and reconstruction of corneal stroma. Composites Part B, 2023, Nov 266; 111004.

3.     Wang G#, Xu L#, Shi R, Ye Y, Zeng B, Yang X, Liu Z, Liu Z, Wang S*, Xue Y*, Li C*. Organotypic culture model of mouse meibomian gland as a screening platform for risk factors related to meibomian gland dysfunction. Ocul Surf. 2023 Aug 22;30:73-84. doi: 10.1016/j.jtos.2023.08.007.

4.     Xu L#, Wang G#, Shi R, Zeng B, Zhang Y, Liu Z, Wang S*, Li C*. A Cocktail of Small Molecules Maintains the Stemness and Differentiation Potential of Conjunctival Epithelial Cells. Ocul Surf, 2023 Aug 25;30:107-118. doi: 10.1016/j.jtos.2023.08.005.

5.     Han Y#, Guo S#, Li Y#, Li J, Zhu L, Liu Y, Lv Y, Yu D, Zheng L, Huang C, Li C*, Hu J*, Liu Z*. Berberine ameliorate inflammation and apoptosis via modulating PI3K/AKT/NFκB and MAPK pathway on dry eye. Phytomedicine. 2023 Sep, 155081. doi: 10.1016/j.phymed.2023.155081.

6.     Yang D, Han Y, Wang Y, Pan Y, Zheng L, Liu Z*, Li C*, Wu Y*, Li H*. Highly effective corneal permeability of reactive oxygen species-responsive nano-formulation encapsulated cyclosporine a for dry eye management. Chem Eng J. 2023; 469: 143968.

7.     Kang H, Han Y, Jin M, Zheng L, Liu Z, Xue Y*, Liu Z*, Li C*. Decellularized squid mantle scaffolds as tissue-engineered corneal stroma for promoting corneal regeneration. Bioeng Transl Med. 2023;e10531.

8.     Xu L, Hou S, Huang X, Wang M, Li C*, Dong N*, Lin Z*. Highly sensitive homogeneous electrochemiluminescence biosensor for microRNA-155 based on enzyme-free cascade signal amplification and magnetic assisted enrichment. J  Elec Chem. 2023, 933: 117274.

9.     Tang Y#, Han Y#, Zhao J, Lv Y, Fan C, Zheng L, Zhang Z, Liu Z*, Li C*, Lin Y*. A Rational Design of a Metal-Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns. Nanomicro Lett. 2023 Apr 30;15(1):112.

10.  Bao X, Zhong Y, Yang C, Chen Y, Han Y, Lin X, Huang C, Wang K*, Liu Z*, Li C*. T-Cell Repertoire Analysis in the Conjunctiva of Murine Dry Eye Model. Invest Ophthalmol Vis Sci. 2023 Mar 1;64(3):14.

11.  Zheng L#, Han Y#, Ye E, Zhu Q, Loh X, Li Z* Li C*. Recent Advances in Ocular Therapy by Hydrogel Biomaterials. World Scientific Annual Review of Functional Materials. 2022: 2230002.

12.  Wang Y#, Kang H#, Jin M, Wang G, Ma W, Liu Z, Xue Y*, Li C*. Phenotypic and Transcriptomics Analyses Reveal Underlying Mechanisms in a Mouse Model of Corneal Bee Sting. Toxins (Basel). 2022 Jul 8;14(7):468.

13.   Mei S, Lin J, Liu Z*, Li C*. A Novel Mutation in the FYCO1 Gene Causing Congenital Cataract: Case Study of a Chinese Family. Dis Markers. 2022 Aug 26;2022:5838104.

14.  Zhong Y#, Fang X#, Wang X, Lin Y, Wu H*, Li C*. Effects of Sodium Hyaluronate Eye Drops With or Without Preservatives on Ocular Surface Bacterial Microbiota. Front Med. 2022 Feb 14;9:793565.

15.  Wang X, Zhong Y, Liang M, Lin Z, Wu H*, Li C*. Crosslinking-Induced Corneal Endothelium Dysfunction and Its Protection by Topical Ripasudil Treatment. Dis Markers. 2022 Jan 13;2022:5179247.

16.  Li W, Li X, Cui F, Xu Z, Dong N*, Li C*. The Ocular Surface Characteristics in Prostate Cancer Patients Treated with Androgen Deprivation Therapy. Dis Markers. 2021 Nov 9;2021:5390195.

17.  Zong R, Zhu F, Han W, Wang Y, Wang G, Wang Y, Mao Y, Guan T, Liu Z, Xue Y*, Li C*. Tear dynamics testing and quantitative proteomics analysis in patients with chronic renal failure. J Proteomics. 2021 Aug 16:104351.

18.  Wang G，An X，Jin M, Wang X, Zong R, Liu Z, Liu Z, Xue Y*, Li C*. Real-time confocal microscopy imaging of corneal cytoarchitectural changes induced by different stresses. Exp Eye Res. 2021 Sep;210:108706.

19.  Li Z, Liu M, Ke J, Wang J, Wu C, Li C*, Li Z*, Wu Y*. Flexible polymeric nanosized micelles for ophthalmic drug delivery: research progress in the last three years. Nanoscale Adv. 2021, 3 (18) , 5240-5254.

20.  Han Y#, Jiang L#, Shi H#, Xu C, Liu M, Li Q, Zheng L, Chi H, Wang Y, Liu Z, You M, Loh X, Wu Y*, Li Z*, Li C*. Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye. Bioact Mater. 2021 Jul 28;9:77-91.

21.  Jin M, Wang Y, An X, Kang H, Wang Y, Wang G, Gao Y, Wu S, Reinach P, Liu Z, Xue Y, Li C*. Phenotypic and transcriptomic changes in the corneal epithelium  following exposure to cigarette smoke. Environ Pollut. 2021 Oct 15;287:117540.

22.  An X, Wang G, Jin M, ZhouX, Gao S, Chen J, Reinach P, Liu Z, Xue Y*, Li C*. Novel Cell Culture Paradigm Prolongs Mouse Corneal Epithelial Cell Proliferative Activity in vitro and in vivo. Front Cell Dev Biol. 2021 Jun 30; 9:675998.

23.  Han Y#, Xu C#, Shi H#, Yu F, Zhong Y, Liu Z, Loh X, Wu Y*, Li Z*, Li C*. Engineered bio-adhesive polyhedral oligomeric silsesquioxane hybrid nanoformulation of amphotericin B for prolonged therapy of fungal keratitis. Chem Eng J. 2021, 421, 129734.

24.  Dong N#*, Cai Q#, Li Z, Xu L, Wu H, Lin Z, Qiu B, Li C*, Lin Z*. Convenient hyaluronidase biosensors based on the target-trigger enhancing of the permeability of a membrane using an electronic balance as a readout. Analyst. 2021 May 17;146(10):3299-3304.

25.  Tao Y, Luo F, Lin Y, Dong N*, Li C*, Lin Z*. Quantitative gold nanorods based photothermal biosensor for glucose using a thermometer as readout. Talanta. 2021 Aug 1;230:122364.

26.  Li X#, Wang X#, Wang Y, Wu H*, Li C*. Effect of Proparacaine Hydrochloride Eye Drops on the Ocular Surface. International Journal of Ophthalmology & Visual Science. 2021; 6(1): 46-53.

27.  Ma W, Wang G, Li X, Wu H, Liu Z, Dong N*, Li C*. Study of Factors Influencing Dry Eye in Rheumatoid Arthritis. J Ophthalmol. 2020 Aug 8;2020:5768679.

28.  Wang G, Chen P, Wang Y, Wang Y, Reinach PS, Xue Y, Liu Z*, Li C*. Onion Epithelial Membrane Scaffolds Transfer Corneal Epithelial Layers in Reconstruction Surgery. Adv Healthc Mater. 2020 Jul;9(14):e2000469.

29.  Jin M, Wang Y, Wang Y, Li Y, Wang G, Liu X, Xue Y*, Liu Z, Li C*. Protective effects on corneal endothelium during intracameral irrigation using N-(2)-L-alanyl-L-glutamine. Front Pharmacol. 2020 Mar 27;11:369.

30.   Wang Y, Zhang Y, Lin Z, Wu H*, Li C*. Case Studies of Mycobacterium abscess Infection after Laser in Situ Keratomileusis. Case Reports in Clinical Medicine, 2019 Dec；8(12): 307-314.

31.  Han Y#, Li C#*, Cai Q, Bao X, Tang L, Ao H, Liu J, Jin M, Zhou Y, Wan Y, Liu Z*. Studies on bacterial cellulose/poly vinyl alcohol (BC/PVA) hydrogel composites as tissue-engineered corneal stroma. Biomed Mater. 2020 Apr 30;15(3):035022.

32.  Wang G, Xue Y, Wang Y, Dong F, Shen M, Zong R, Liu Z*, Li C*. The role of autophagy in the pathogenesis of exposure keratitis. J Cell Mol Med. 2019 Jun;23(6):4217-4228.

33.  Yang Q, Tang L, Shen M, Wang Y, Wei Y, Jeyalatha V, Chen P, Dong F, Wang G, Wu S, Liu Z*, Li C*. Effects of diesel exhaust particles on the condition of mouse ocular surface. Ecotoxicol Environ Saf. 2018 Nov 15;163:585-593.

34.  Wang G, Dong N, Wang Y, Li J, Dong F, Jeyalatha V, Wu J, Shen M, Yang Q, Chen P, Xue Y, Liu Z, Li C*. Epithelial dysplasia in pterygium postoperative granuloma. Exp Eye Res. 2018 Oct;175:199-206.

35.  Li J#, Li C#, Wang G, Liu Z, Chen P, Yang Q, Dong N, Wu H, Liu Z*, Li W*. APR-246/PRIMA-1Met Inhibits and Reverses Squamous Metaplasia in Human Conjunctival Epithelium. Invest Ophthalmol Vis Sci. 2016 Feb;57(2):444-52.

36.  Li C, Dong N, Wu H, Dong F, Xu Y, Du H, He H, Liu Z*, Li W*. A novel method for preservation of human corneal limbal tissue. Invest Ophthalmol Vis Sci. 2013 Jun 10;54(6):4041-7.

37.  Li C, Dong F, Jia Y, Du H, Dong N, Xu Y, Wang S, Wu H, Liu Z*, Li W*. Notch signal regulates corneal endothelial-to-mesenchymal transition. Am J Pathol. 2013 Sep;183(3):786-95.

38.  Li C, Yin T, Dong N, Dong F, Fang X, Qu YL, Tan Y, Wu H, Liu Z*, Li W*. Oxygen tension affects terminal differentiation of corneal limbal epithelial cells. J Cell Physiol. 2011 Sep;226(9):2429-37.

39.  Dong N, Qin W, Xue Y, Li C*, Liu Z*. Hypoxia affects in vitro proliferation and differentiation of mouse corneal epithelial progenitor cell. In Vitro Cell Dev Biol Anim. 2013, 49(7), 508-514.

40.  Dong N#, Li C#, Chen W, Qin W, Xue Y, Wu H, Fibrin glue-assisted for the treatment of corneal perforations using glycerin-cryopreserved corneal tissue, Int J Ophthalmol, 2014, 7(1), 62-65.